Category: Biophysics

E. coli in Motion by Howard C. Berg

By Howard C. Berg

The bacterium Escherichia coli - E. coli for brief - has lengthy been the organism of selection for unraveling biochemical pathways, interpreting the genetic code, studying how DNA is replicated and skim, or even for production proteins of business curiosity. For a few thirty years, it additionally has been a version for learning the molecular biology of habit. E. coli swims in a useful demeanour, propelled by way of lengthy skinny helical filaments, each one pushed at its base by way of a reversible rotary engine. As a microscopic organism immersed in an aqueous surroundings, it has mastered actual constraints completely diverse from any that we all know, devising sensors, comparators, and automobiles at the nanometer scale.

This cross-disciplinary monograph describes those feats in a way obtainable to scientists, engineers, and others now not informed in microbiology who want to examine extra approximately dwelling machines. It treats the background of the topic, the body structure, physics, biochemistry and genetics, mostly from first rules. it's all a few small yet remarkably refined good friend who lives on your intestine.

Topics mentioned comprise:

- How does E. coli flow approximately? - How do cells come to a decision no matter if existence is recuperating or worse? - what's the equipment that makes this habit attainable? - How is the development of this equipment programmed? - How does this equipment paintings? - What is still found?

Show description

Continue Reading →

Identification and Quantification of Drugs, Metabolites and by Swapan Chowdhury

By Swapan Chowdhury

As new concepts of moving from liquid to gasoline part and measuring plenty of drug molecules and metabolites turn into extra wide-spread, so do the technical demanding situations of placing those concepts into right use, in addition to the duty of consolidating rising purposes. id and Quantification of substances, Metabolites and Metabolizing Enzymes by way of LC-MS, quantity 6 fills the space within the loss of almost immediately to be had literature through supplying a severe evaluation within the present use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and improvement. With chapters written by means of specialists with a variety of sensible event from the pharmaceutical undefined, emphasis is put on suggestions and purposes. The booklet additionally contains chapters on tips to make the most of LC-MS instrumentation for present drug metabolism difficulties. This e-book is meant for these commencing to use LC-MS for drug metabolism reviews in addition to for these thought of complex practitioners. * Introduces readers to the sensible functions of recent liquid chromatography-mass spectrometry (LC-MS) in quite a lot of drug metabolism studies?ยท* offers a complete description of alternative varieties of metabolites, with certain dialogue at the wide variety of methodologies used to spot them* Highlights difficulties linked to drug quantification and provides useful options

Show description

Continue Reading →

Biomathematics: Mathematics of Biostructures and Biodynamics by S. Andersson, K. Larsson, M. Larsson, M. Jacob

By S. Andersson, K. Larsson, M. Larsson, M. Jacob

This ebook provides new arithmetic for the outline of constitution and dynamics in molecular and mobile biology. On an exponential scale it really is attainable to mix capabilities describing internal organization, together with finite periodicity, with capabilities for outdoor morphology right into a entire definition of constitution. This arithmetic is especially fruitful to use at molecular and atomic distances. The constitution descriptions can then be concerning atomic and molecular forces and supply info on structural mechanisms. The calculations were focussed on lipid membranes forming the outside layers of mobilephone organelles. Calculated surfaces characterize the mid-surface of the lipid bilayer. Membrane dynamics resembling vesicle shipping are defined during this new language. Periodic membrane assemblies show conformations in keeping with the status wave oscillations of the bilayer, thought of to mirror the genuine dynamic nature of periodic membrane constructions. for instance the constitution of an endoplasmatic reticulum has been calculated. The transformation of such telephone membrane assemblies into cubosomes turns out to mirror a transition into vegetative states. The organization of the lipid bilayer of nerve cells is analyzed, making an allowance for an previous saw lipid bilayer part transition linked to the depolarisation of the membrane. facts is given for a brand new constitution of the alveolar floor, concerning the mathematical floor defining the bilayer corporation to new experimental info. the outside layer is proposed to include a coherent section, inclusive of a lipid-protein bilayer curved based on a classical floor - the CLP floor. with out applying this new arithmetic it's going to no longer be attainable to provide an analytical description of this constitution and its deformation in the course of the breathing cycle. in additional basic phrases this arithmetic is utilized to the outline of the constitution and dynamic houses of motor proteins, cytoskeleton proteins, and RNA/DNA. On a macroscopic scale the motions of cilia, sperm and flagella are modelled. This mathematical description of organic constitution and dynamics, biomathematics, additionally presents major new details as a way to comprehend the mechanisms governing form of dwelling organisms.

Show description

Continue Reading →

Tropenkrankheiten und Molekularbiologie - Neue Horizonte by Mechthild Regenass-Klotz, Urs Regenass

By Mechthild Regenass-Klotz, Urs Regenass

Tropenkrankheiten sind f?r viele L?nder zunehmend eine wirtschaftliche und soziale Belastung. Die Molekularbiologie untersucht die Infektionsmechanismen auf molekularer Ebene und tr?gt dazu bei, neue Therapieformen zu entwickeln. Das Buch beleuchtet wichtige Tropenkrankheiten in je einem eigenen Kapitel - mit Schwerpunkt auf aktuellen molekularbiologischen Erkenntnissen. Die leicht verst?ndlichen Texte sind eine fundierte Informationsquelle f?r Mediziner und Biologen, aber auch f?r Tropenreisende. Mit Glossar und Stichwortregister.

Show description

Continue Reading →

Advances in Chemical Physics, Volume 158: Physical Chemistry by Mitsuru Nagasawa

By Mitsuru Nagasawa

The Advances in Chemical Physics sequence offers the chemical physics box with a discussion board for severe, authoritative reviews of advances in each quarter of the self-discipline. This quantity explores subject matters from Thermodynamic houses of Polyelectrolyte recommendations to ion-binding of polyelectrolytes. The e-book features:

  • The purely sequence of volumes to be had that offers the innovative of study in chemical physics
  • Contributions from specialists during this box of research
  • Representative cross-section of study that questions confirmed pondering on chemical solutions
  • An editorial framework that makes the e-book an exceptional complement to a complicated graduate classification in actual chemistry or chemical physics

Show description

Continue Reading →