Advances in Stereotactic and Functional Neurosurgery 9: by Dr. R. Martínez, J. Vaquero, L. V. De La Morena, F.

By Dr. R. Martínez, J. Vaquero, L. V. De La Morena, F. Tendillo, P. Aragonés (auth.), Professor Edward R. Hitchcock, Prof. Dr. Giovanni Broggi, Dr. Juan Burzaco, Dr. J. Martin-Rodriguez, Dr. Björn A. Meyerson, Dr. Szabolcs Tóth (eds.)

The ebook provides the main up to date details for the increasing box of stereotactic and useful neurosurgery from eu and foreign specialists. the most recent advancements in neural transplantation and stereotactic irradiation are incorporated including the reviews on wide trials of analgesic surgical procedure and new innovations utilized in the therapy of various useful disorders.

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Additional info for Advances in Stereotactic and Functional Neurosurgery 9: Proceedings of the 9th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Malaga 1990

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Ben, Department of Neurosurgery and Endocrinology, Dalian Municipal Central Hospital, Dalian, China. Acta Neurochirurgica, Suppl. 52,45-47 (1991) © by Springer-Verlag 1991 Adrenal Medulla Autograft in Caudate Nucleus as Treatment for Parkinson Disease G. BroggP, F. Pluchino 1 , L. GennarP, S. GeminianF, F. Tamma 2 , and T. CaracenF Departments of1Neurosurgery, 2Neurology, Istituto Neurologico "c. Besta" Department of 30ncological Surgery, Istituto Nazionale dei Tumori, Milano, Italy Summary The personal experience of four Parkinson's disease patients operated on with adrenal medulla autograft in the caudate nucleus is reported.

1. M. 2 o 0 pre 7 3 14 21 26 pre 3 _ 'ham _ days Implant _ Fig. 1. 01) 15 points Sham _ Implant Fig. 2. Paw pinch test results in sham and adrenal medullary implanted arthritic rats 6 sciatic section 4 26 21 14 7 days 15 points rhizotomy 4 3 3 2 2 O ~-------r-------'--------,-------~ o 7 14 21 7 26 days -+- aham -+- sham ---- Implant a 14 21 28 days Implant b Fig. 3. Average autotomy score in sciatic sectioned (a) and cervical posterior rhizotomized rats (b). 05; Mann Whitney test). Figure 3(b) shows the mean autotomy scores reached by both experimental groups.

Thus, in an animal with a 37 Towards a Neural Transplantation Therapy for Parkinson's Disease wide range of symptoms associated with extensive forebrain dopamine depletion, distinct classes of symptoms are affected by grafts placed into discrete target sites. Moreover, multiple grafts have an additive effect, reversing the full range of impairments associated with each of the individual placements. Whereas the caudate and putamen are not differentiated in rats, these nuclei are quite distinct in primate species, including man.

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